Endocrine Abstracts

Background and aim: Obesity is a chronic disease associated with a positive energy balance leading to lipotoxicity, which contributes to the onset of obesity-associated metabolic disorders such as type 2 diabetes and insulin resistance. It’s well known that thermogenesis in brown adipose tissue (BAT) and “browning” of white AT (WAT) increase energy expenditure, thus promoting weight loss and protect against obesity. Recently, the microRNAs (miRNAs) that regulate...

An 18-years-old woman without medical history was referred for study of hypertension and an adrenal incidentaloma. The family history was significant for essential well-controlled hypertension in her father; diagnosed at 39 years-old. The patient complained of headache, asthenia, edema in lower limbs, high blood pressure values (200/150 mmHg) for one year (well controlled with losartan 100 mg/12 h, amlodipine 10 mg/24 h and doxazosin 4 mg/24 h) and marked facial acne previous ...

Introduction: Glycogenosis is a group of hereditary diseases affecting the glycogen metabolism, due to mutations in enzymes involved in the transformation and synthesis of glucose (liver and muscle glycogenosis). Brain germ tumors are very infrequent. They are located mainly in pineal and sellar region. Central diabetes insipidus is the most frequent manifestation. Their prognosis and response to combined chemo/radiotherapy treatment are favorable.Case r...

We present the clinical case of a family with an initial diagnosis of AIP syndrome with AIP mutation and a secondary diagnosis of MEN syndrome associated because of a large MEN-1 gen deletion. A male patient 16 years old was evaluated because of delayed growth and pubertal development. He had headaches, nausea and vomits since seven years old. MRI showed: Large pituitary mass of 47.6×22×47.2 mm that erode the floor of the sella, extending into the left prepontine cis...

Introduction: DNA methylation is one of the epigenetic mechanisms existing to regulate gene expression. It is believed that methylation of DNA is susceptible of change by environmental and nutritional factors. Thus, epigenetics provides a mechanism which may explain the etiology of some metabolic disorders and obesity.Aim: The aim of this study is to analyze the DNA methylation level of several lipoprotein lipase (LPL)-promoter-CpG island in human viscer...

Objectives: To study for the first time the differences in monocyte/macrophage infiltration, inflammation and adipogenesis in the subcutaneous and visceral adipose tissues of normal-weight subjects who differed in their degree of metabolic syndrome.Methods: The study included 92 normal-weight subjects who differed in their degree of metabolic syndrome. Anthropometric and biochemical parameters were measured. RNA from subcutaneous and visceral adipose tis...

Introduction: Obesity is characterized by a low-grade inflammatory state which has been directly related to the development of insulin resistance and diabetes. Circulating lipopolysaccharides (LPS) have been proposed as a triggering factor for this inflammation. Likewise, adipose tissue (AT) capacity for lipid handling and storage is also a key factor for the development of obesity-related metabolic disorders. Animal studies have shown that LPS are able to modify the expressio...

Introduction: Ghrelin is a gastrointestinal peptide involved in the regulation of body weight and energy balance. However, its behavior after bariatric surgery and its relationship with other biochemical variables is still under discussion. We aim to undertake a simultaneous evaluation of the changes in ghrelin levels after three types of bariatric surgery and its relationship with different variables.Design: The study included 21 non-obese and 103 morbi...

Introduction: Parenteral nutrition (PN) is indicated in patients in which gastrointestinal tract is inaccessible or is severely affected. In our hospital, specialists often use commercial three-compartment bags of PN that provide standard nutritional requirements regardless a total parenteral nutrition (TPN) with macro and micronutrients adjusted to each patient by Endocrinology and Nutrition Service.Objectives: To assess the use of commercial premixed P...

Adrenal insufficiency is a common complication of transsphenoidal surgery (TSS) for pituitary adenoma. It is very important to identify patients requiring glucocorticoid replacement, minimising risks of adrenal insufficiency.Aim: To assess the performance of early (3° day) post-TSS 08:00 a.m. cortisol measurement to detect and exclude secondary adrenal insufficiency.Methods: We selected patients undergoing TSS in our hospital ...